The patient pictured presents to your clinic for follow up of rosacea. He has tried various topicals in the past, but still feels he is developing new papules and pustules on the face. You decide to prescribe a course of oral doxycycline. Which of the following is FALSE in regard to the use of doxycycline in rosacea?
A.) The patient should be counseled about possible esophagitis as a side effect
B.) Doxycycline exhibits its anti-inflammatory effect via downregulation of inflammatory cytokines such as IL-1 and TNF-aas well as inhibition of matrix metalloproteases
C.) Doses totaling 100 mg daily delivered either QD or BID are needed to achieve full anti-inflammatory potential
D.) Photosensitivity is a dose-dependent side effect
E.) Doxycycline exerts its antimicrobial effect via binding of ribosomal subunits